Gabapentin is an anticonvulsant drug that helps patients with epilepsy manages their seizures. Certain gabapentin formulations may also be used to treat restless legs syndrome (RLS) and certain kinds of nerve discomfort.
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How Gabapentin Works:
- Gabapentin is a medication that may be used to treat some types of seizures or nerve pain.
- Although experts are unsure precisely how gabapentin works, research has shown that gabapentin tightly binds to a particular location on voltage-gated calcium channels called the alpha2-delta site. This is believed to be the mechanism by which it alleviates nerve pain and reduces the likelihood of seizures.
- Gabapentin enacarbil (brand name Horizant) is a gabapentin prodrug that was developed to address gabapentin's limitations, including low absorption and a short duration of effect. Restless legs syndrome (RLS) and postherpetic neuralgia are effectively treated with gabapentin enacarbil (nerve pain that occurs following Shingles).
Upsides:
- May be used in conjunction with other medications to help adults and children aged three and older with partial-onset seizures have fewer seizures.
- May be used to treat people suffering from postherpetic neuralgia (persistent nerve pain caused by shingles infection).
- Restless legs syndrome (RLS) and nerve discomfort associated with postherpetic neuralgia may be treated with gabapentin enacarbil (brand name Horizant). This gabapentin prodrug needs just a once-daily dose.
- Generic gabapentin is available; however, not all generics are compatible with certain branded gabapentin formulations.
- Gabapentin may be used off-label (meaning it may be used for a condition that has not been recognised by the FDA but may still have a role in treatment) for some medical conditions, including fibromyalgia, recurrent hiccups, migraine prophylaxis, and hot flashes.
Downsides:
- People between 18 and 60 years old who are not taking any other medications or have a medical condition may be more susceptible to the following negative effects:
- Symptoms include dizziness, sleepiness, fatigue, fever, and nystagmus (a rapid and uncontrollable movement of the eyes). Gabapentin-induced drowsiness may impair your ability to drive or operate machines. Alcohol and other sleepy substances amplify this impact.
- When used to cure epilepsy in kid’s ages three to twelve years, this medication may induce behavioral issues, anger or violence, or thinking disorders.
- Additionally, impaired vision, amblyopia (lazy eye), dry mouth, peripheral oedema (fluid retention in the feet and hands), tremor, sexual dysfunction, and gastrointestinal problems are possible adverse effects.
- To minimise the possibility of adverse effects, it is best to gradually increase the dose; nevertheless, this may delay the beginning of an effect.
- Gabapentin, like other anticonvulsant medications, may raise the risk of depression and suicidal ideation, especially in adolescents and young people under the age of 24.
- When suddenly discontinued, gabapentin has been linked with a discontinuation syndrome. Anxiety, sleeplessness, nausea, discomfort, and excessive perspiration are among the symptoms. It should be gradually weaned down with the assistance of a physician.
- Gabapentin dose should be lowered in patients with renal dysfunction.
- Hypersensitivity responses are quite rare. Fever, rash, enlarged lymph nodes, swollen facial features, and throat swelling are all possible symptoms.
- May interact with some other medicines, such as antacids, hydrocodone, morphine, and other sedative or dizzying medications. Additionally, it may provide false-positive findings on some urine protein tests.
- There have been instances of gabapentin overuse and abuse, especially among individuals with a history of substance dependence. Be on the lookout for this possibility.
- Gabapentin must be taken three times daily due to its limited duration of action. Gabapentin enacarbil (brand name Horizant) is a once-daily dose medication.
- Effective only in the treatment of partial-onset seizures; not in the treatment of other forms of seizure disorders.
- Certain formulations of gabapentin, both branded and generic, are not interchangeable.
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